GLP-1 weight loss treatment in India: tirzepatide and semaglutide, supervised by doctors
Weekly medicines such as Mounjaro (tirzepatide) and Wegovy (semaglutide) can make weight loss far more achievable for the right person. At Lean Life they are prescribed only after a medical assessment, started at a low dose and monitored at every step.
Medically reviewed and approved by Dr Reina Punj, MBBS, PG Diploma in Endocrinology (UK), Lead Physician. Approved on 24 October 2026.
How GLP-1 medicines work
GLP-1 is a hormone your gut releases after you eat. GLP-1 medicines copy it: they reduce appetite, help you feel full sooner and slow how quickly your stomach empties. Tirzepatide also acts on a second gut hormone, GIP. Both are injected once a week with a small pen.
In December 2025, the World Health Organization issued its first guideline on GLP-1 medicines for obesity, recommending them for adults alongside diet and activity support, prescribed by qualified professionals.
Read more about each medicine: Mounjaro, Wegovy and generic semaglutide.
| Mounjaro | Wegovy | Generic semaglutide | |
|---|---|---|---|
| Medicine | Tirzepatide | Semaglutide | Semaglutide |
| Maker | Eli Lilly | Novo Nordisk | Several Indian makers, since March 2026 |
| How often | Once a week | Once a week | Once a week |
| Average loss in major trials | 20.9% at 15 mg over 72 weeks (SURMOUNT-1) | About 15% at 2.4 mg over 68 weeks (STEP 1) | Same molecule as Wegovy; check the brand is approved for weight management |
| From, per month | ₹13,125* | ₹5,660* | ₹1,500* (Semasize) |
* Prices are manufacturers' maximum retail prices (MRP) in India, checked October 2026, and are shown as a guide only. Prices change often and may differ when you buy. Lean Life does not sell medicines online: any medicine is prescribed only after a consultation with a Lean Life doctor, and dispensed by a licensed pharmacy.
Who it is for, and who should not take it
GLP-1 medicines are usually considered for adults with a BMI of 30 or more, or 27 or more with a weight-related condition such as prediabetes, high blood pressure or sleep apnoea. Doctors in India also weigh lower Asian cut-offs, because health risks start at lower weights.
They are not suitable during pregnancy or breastfeeding, or for people with a personal or family history of medullary thyroid cancer or MEN 2 syndrome. A past episode of pancreatitis needs careful review. Your doctor checks all of this at your assessment.
See where your BMI falls before you book.
Check eligibilityHow Lean Life prescribes and monitors
First
Advisor call
Free. Your questions answered and a doctor's visit booked.
Before
Doctor assessment
History, blood tests and InBody, to confirm the medicine is safe and suitable.
Month 1
Lowest dose
You start low so your body can adjust, with a high-protein nutrition plan.
Every 4 weeks
Step up if needed
The dose rises only if you are tolerating it and still need it.
Throughout
Protect muscle
InBody re-tests show fat lost and muscle kept, and the plan adjusts.
At your goal
Planned step-down
Many people regain weight after stopping without a plan, so we step down with you.
Side effects to know about
The most common are digestive: nausea, constipation, diarrhoea and feeling full quickly, usually in the first weeks and after a dose increase. Starting low and eating smaller meals helps.
Rare but serious problems include pancreatitis and gallbladder trouble. Severe, lasting pain in the upper belly needs urgent medical attention. Your doctor will explain what to watch for and how to reach the clinic.
Frequently asked questions
Which is better, Mounjaro or Wegovy?
In trials tirzepatide led to more weight loss on average, but semaglutide costs less, especially as a generic. Your doctor recommends one based on your health, budget and goals.
How long will I need to take it?
It varies. Most plans run for several months, followed by a supervised step-down and maintenance.
Can I start online?
Yes. Assessment and follow-ups can be online, with tests arranged near you or at our Nariman Point clinic.
Will I lose muscle?
Fast weight loss can include muscle. That is why we set a protein target and track muscle with InBody throughout.
Start with a conversation, not a prescription.
Free advisor call, Monday to Saturday, 10 am to 6 pm, in English or Hindi.